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BEGIN:VEVENT
SUMMARY:特徴あるプログラム CIBoG/AI-MAILs オミクス解析学
DTSTART;VALUE=DATE-TIME:20260312T081500Z
DTEND;VALUE=DATE-TIME:20260312T094500Z
UID:111452832632
DESCRIPTION:2026 年度 基盤医学特論 開講通知 Information on Spe
 cial Lecture Tokuron &amp\; Tokupro AY2026特徴あるプログラム CIBo
 G/AI-MAILs オミクス解析学プログラム CIBoG/AI-MAILs Omics Analy
 sisTitle： We are what we eat! Western lifestyle\, metaflammation and th
 e cell of  origin of colon cancer.講師：Riccardo Fodde\, PhD　　　D
 epartment of Pathology\, Erasmus University Medical          Center\
 , Rotterdam\, the Netherlands.                日時：2026年 3
 月12日（木）17：15～18：45 (鶴友会館 2階 大会議室) Time
  and Date：12th March\, 2026 17:15-18:45 (2F Large conference room\, Kaku
 yu Kaikan)使用言語：英語　English概説：Phenotypic plasticity\, 
 i.e. the capacity of a single cell with a given genotype to acquire multip
 le phenotypes as a function of its environment\, represents one of the mos
 t clinically relevant hallmark of cancer as it plays a rate-limiting role 
 along the invasion-metastasis cascade. Somewhat surprisingly\, we discover
 ed that phenotypic plasticity also plays a crucial role in tumor onset (in
 itiation) and in determining the identity of the cell-of-origin of cancer.
 In cancer biology\, the dogma predicts that virtually all cancers are init
 iated in stem cells. By using mouse models and patient-derived colon cance
 rs\, we have recently shown that a significant proportion of colon cancers
  are in fact initiated in post mitotic and fully differentiated cell linea
 ges. In the context of inflammation\, while resident stem cells are suppre
 ssed\, differentiated cells de-differentiate and acquire specific stem-lik
 e features thus contributing to tissue regeneration. However\, this mechan
 ism will also increase the relative number of cell targets of tumor initia
 tion. Moreover\, the prognosis of tumors arisen from differentiated lineag
 es appears to be distinct (decreased overall survival and a more pronounce
 d inflammatory profile) from those derived from stem cells.These results c
 an be explained by the recent observation according to which Western lifes
 tyles and in particular Western-style dietary habits can cause a low-grade
  but chronic and metabolic inflammation (called metaflammation)\, which mi
 ght prime committed cell lineages to initiate colon tumorigenesis. At-risk
  individuals might include cases of early-onset colon cancer\, the inciden
 ce of which has risen dramatically in the past few decades.関係講座:
 分子遺伝学（データ駆動生物学、分子腫瘍学）部門等
 の連絡担当者:分子腫瘍学　水野（内線5190）Contact：Divis
 ion of Molecular Oncology  Mizuno（ext.5190）※講義室にて開催
 します。This lecture is held through Lecture Room.※事前のお申
 し込みは不要です。  No Registration required.※講義開始後
 の30分までにご入室下さい。  Please take a seat before 17:45.
 ※途中退室不可  Please stay until the end of the lecture.
LOCATION:鶴友会館 2階 大会議室
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