BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//chikkutakku.com//RDFCal 1.0//EN
X-WR-CALDESC:GoogleカレンダーやiCalendar形式情報を共有シェ
 アしましょう。近所のイベントから全国のイベントま
 で今日のイベント検索やスケジュールを決めるならち
 っくたっく
X-WR-CALNAME:ちっくたっく
X-WR-TIMEZONE:UTC
BEGIN:VEVENT
SUMMARY:基盤医学特論　ウイルス学
DTSTART;VALUE=DATE-TIME:20251127T040000Z
DTEND;VALUE=DATE-TIME:20251127T053000Z
UID:326334882786
DESCRIPTION:Title:  HDAC6 is A Critical Regulator at the Intersection of 
 Deacetylation\, Ubiquitination\, and Cellular Stress Responses            
                 Histonedeacetylases (HDACs) regulate histone acetylation l
 evels\, significantlyimpacting gene expression and various cellular proces
 ses. As a result\, they arevalidated drug targets in cancer and other path
 ologies. Among them\, HDAC6 is aunique deacetylase with tandem catalytic d
 omains and a C-terminal zinc finger(ZnF-UBP) domain that binds to unanchor
 ed ubiquitin with high affinity. Unlikethe major class I HDACs that primar
 ily regulate transcription\, HDAC6predominantly localizes to the cytoplasm
 . Here\, its key substrates includealpha-tubulin\, cortactin\, HSP90\, and
  DDX3X\, among others. HDAC6 is recognizedas a central modulator of stress
  responses and autophagic clearance\, criticalfor the formation of aggreso
 mes and stress granules. More recently\, HDAC6 hasbeen implicated in viral
  infection\, controlling a critical early step in theprocess. We will disc
 uss recent findings illustrating the importance of HDAC6in the stress resp
 onse and demonstrating that the capacity of HDAC6 to recruitubiquitin chai
 ns (whether viral or cellular) is critical for the uncoating andinfection 
 by influenza and other viruses.講師：パトリック　マティアス
 　教授（FMI\, バーゼル大学　スイス）Teaching Staff: Prof. P
 atrick Matthias (FriedrichMiescher Institute for Biomedical Research\, Uni
 versity of Basel\, Switzerland) 日時：令和7年11月27日(木)　13
 時00分より（90分）Time and Date: November 27 (Thu.)\, 2025  13 : 0
 0～　(90 minutes) 場所：医系研究棟3号館3階　会議室Room: 
 MeetingRoom\, (3rd Medical Research Building\, 3rd floor) 言語： 英
 語Language: English ※関係専門分野・講座等の連絡担当者
 ：ウイルス学　三宅康之・木村宏（内線 2451）Contact:Yasu
 yuki Miyake and Hiroshi Kimura\, Division of Virology (Ext. 2451)（事前
 の申込みは不要です。NoRegistration Required.） 
LOCATION:医系研究棟3号館３階　会議室　
END:VEVENT
END:VCALENDAR