基盤医学特論　ウイルス学

基盤医学特論　ウイルス学

Title:  HDAC6 is A Critical Regulator at the Intersection of Deacetylation, Ubiquitination, and Cellular Stress Responses Histonedeacetylases (HDACs) regulate histone acetylation levels, significantlyimpacting gene expression and various cellular processes. As a result, they arevalidated drug targets in cancer and other pathologies. Among them, HDAC6 is aunique deacetylase with tandem catalytic domains and a C-terminal zinc finger(ZnF-UBP) domain that binds to unanchored ubiquitin with high affinity. Unlikethe major class I HDACs that primarily regulate transcription, HDAC6predominantly localizes to the cytoplasm. Here, its key substrates includealpha-tubulin, cortactin, HSP90, and DDX3X, among others. HDAC6 is recognizedas a central modulator of stress responses and autophagic clearance, criticalfor the formation of aggresomes and stress granules. More recently, HDAC6 hasbeen implicated in viral infection, controlling a critical early step in theprocess. We will discuss recent findings illustrating the importance of HDAC6in the stress response and demonstrating that the capacity of HDAC6 to recruitubiquitin chains (whether viral or cellular) is critical for the uncoating andinfection by influenza and other viruses.講師：パトリック　マティアス　教授（FMI, バーゼル大学　スイス）Teaching Staff: Prof. Patrick Matthias (FriedrichMiescher Institute for Biomedical Research, University of Basel, Switzerland) 日時：令和7年11月27日(木)　13時00分より（90分）Time and Date: November 27 (Thu.), 2025  13 : 00～　(90 minutes) 場所：医系研究棟3号館3階　会議室Room: MeetingRoom, (3rd Medical Research Building, 3rd floor) 言語： 英語Language: English ※関係専門分野・講座等の連絡担当者：ウイルス学　三宅康之・木村宏（内線 2451）Contact:Yasuyuki Miyake and Hiroshi Kimura, Division of Virology (Ext. 2451)（事前の申込みは不要です。NoRegistration Required.） 

📍 医系研究棟3号館３階　会議室　

🔖 大学院特論（公開中）