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2026 年度 基盤医学特論 開講通知 Information on Special Lecture Tokuron & Tokupro AY2026特徴あるプログラム CIBoG/AI-MAILs オミクス解析学プログラム CIBoG/AI-MAILs Omics AnalysisTitle： We are what we eat! Western lifestyle, metaflammation and the cell of origin of colon cancer.講師：Riccardo Fodde, PhD Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands. 日時：2026年 3月12日（木）17：15～18：45 (鶴友会館 2階 大会議室) Time and Date：12th March, 2026 17:15-18:45 (2F Large conference room, Kakuyu Kaikan)使用言語：英語 English概説：Phenotypic plasticity, i.e. the capacity of a single cell with a given genotype to acquire multiple phenotypes as a function of its environment, represents one of the most clinically relevant hallmark of cancer as it plays a rate-limiting role along the invasion-metastasis cascade. Somewhat surprisingly, we discovered that phenotypic plasticity also plays a crucial role in tumor onset (initiation) and in determining the identity of the cell-of-origin of cancer.In cancer biology, the dogma predicts that virtually all cancers are initiated in stem cells. By using mouse models and patient-derived colon cancers, we have recently shown that a significant proportion of colon cancers are in fact initiated in post mitotic and fully differentiated cell lineages. In the context of inflammation, while resident stem cells are suppressed, differentiated cells de-differentiate and acquire specific stem-like features thus contributing to tissue regeneration. However, this mechanism will also increase the relative number of cell targets of tumor initiation. Moreover, the prognosis of tumors arisen from differentiated lineages appears to be distinct (decreased overall survival and a more pronounced inflammatory profile) from those derived from stem cells.These results can be explained by the recent observation according to which Western lifestyles and in particular Western-style dietary habits can cause a low-grade but chronic and metabolic inflammation (called metaflammation), which might prime committed cell lineages to initiate colon tumorigenesis. At-risk individuals might include cases of early-onset colon cancer, the incidence of which has risen dramatically in the past few decades.関係講座:分子遺伝学（データ駆動生物学、分子腫瘍学）部門等の連絡担当者:分子腫瘍学 水野（内線5190）Contact：Division of Molecular Oncology Mizuno（ext.5190）※講義室にて開催します。This lecture is held through Lecture Room.※事前のお申し込みは不要です。 No Registration required.※講義開始後の30分までにご入室下さい。 Please take a seat before 17:45.※途中退室不可 Please stay until the end of the lecture.
📍 鶴友会館 2階 大会議室